INAA and EDXRF applications in the age dynamics assessment of Zn content and distribution in the normal human prostate

An INAA, EDXRF and morphometric study was carried out to determine the zinc content and distribution in 87 prostates of health males aged from 5 days to 87 years. Also, an EDXRF method was used to determine zinc content in prostate fluid samples taken from 22 subjects aged 18 to 75. It was shown that intracellular zinc content increased highly in men over 40 years old. A hypothesis was suggested that excess of intracellular zinc might play an important role at both initiation and promotion stages of prostate carcinogenesis. This revised version was published online in July 2006 with corrections to the Cover Date.