A review on 90Y-labeled compounds and biomolecules |
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| Authors: | Tanveer Hussain Bokhari Muhammad Bilal Butt Saira Hina Munawar Iqbal Muhammad Daud Muhammad Imran |
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| Affiliation: | 1.Department of Chemistry,Government College University,Faisalabad,Pakistan;2.Government College Women University,Faisalabad,Pakistan;3.Department of Chemistry,University of Lahore,Lahore,Pakistan;4.QCG, Pakistan Institute of Nuclear Science and Technology,Islamabad,Pakistan;5.Institute of Chemistry,University of the Punjab,Lahore,Pakistan |
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| Abstract: | The field of therapeutic nuclear medicine is emerging rapidly as choice of treatment in oncology and other cellular malignancies. The growth of this branch of nuclear medicine is greatly facilitated by the introduction of a number of new radiopharmaceuticals and radionuclides. 90Y-radiopharmaceuticals have confirmed their worth in medical and clinical areas in a very short span of time. The 90Y is a radioisotope widely used for therapeutic purposes and considerable perfection has been made to understand the chemistry of 90Y-labeled radiopharmaceuticals. The development of these radiopharmaceuticals can be made favorable by using appropriate buffer, incubation period, optimal pH, specific activity and reaction temperature. In this review, we have discussed the preparation of range of 90Y transporting biological molecules such as antibodies radiolabeled peptides, antigens and microsphere with their clinical applications. |
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