| 19F NMR的特点 |
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| 引用本文： | 李临生,李燕,兰云军,张建华. 19F NMR的特点[J]. 波谱学杂志, 2007, 24(3): 353-364 |
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| 作者姓名： | 李临生 李燕 兰云军 张建华 |
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| 作者单位： | 温州大学,浙江省皮革重点实验室,浙江,温州,325027;陕西科技大学,应用化学研究所,陕西,咸阳,712081;温州大学,浙江省皮革重点实验室,浙江,温州,325027;陕西科技大学,应用化学研究所,陕西,咸阳,712081 |
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| 摘 要： | 19F的磁旋比和相对灵敏度接近质子；19F NMR化学位移范围可达 δ 1 000，谱图分辨率高；19F NMR对环境因素较氢谱远为敏感、复杂，可反映出化合物结构的细微差别. 由于正常生物体内含氟成分很少，干扰小，因此在生物医学研究中引入氟代物进行19F NMR研究有特殊意义. 对氟化物的19F NMR化学位移和偶合常数的范围也分类作了总结.
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| 关 键 词： | 19F NMR 有机氟 氟化物 化学位移 偶合常数 生物医学 |
| 文章编号： | 1000-4556（2007）03-0353-12 |
| 收稿时间： | 2006-11-20 |
| 修稿时间： | 2006-11-202007-01-15 |
A Brief Review on 19F NMR |
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| LI Lin-sheng,LI Yan,LAN Yun-jun,ZHANG Jian-hua. A Brief Review on 19F NMR[J]. Chinese Journal of Magnetic Resonance, 2007, 24(3): 353-364 |
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| Authors: | LI Lin-sheng LI Yan LAN Yun-jun ZHANG Jian-hua |
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| Affiliation: | 1. Key Laboratory of Leather, Zhejiang Province, Wenzhou University, Wenzhou 325027, China；2. Institute of Applied Chemistry, Shaanxi University of Science and Technology, Xianyang 712081, China |
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| Abstract: | Fluorine-19 (19F) isotope has 100% natural abundance, and the magnetic moment and relative NMR sensitivity of 19F nuclei are similar to those of 1H nuclei. The total range of 19F NMR chemical shifts is over δ 1 000, giving good spectral resolution. Compared to 1H NMR, 19F NMR is more sensitive to the changes in molecular structure and environmental factors, and thus can be used to probe fine structural difference of the compounds. In vivo 19F NMR spectroscopy provides a highly specific tool for identifying the existence of fluorine-containing drugs and their metabolites in the tissue. In this paper, the 19F chemical shifts and coupling constants of various fluorine-containing compounds were summarized and reviewed. |
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| Keywords: | ~(19)F NMR organic fluorine fluorine-containing compound chemical shift coupling constant |
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