Spectroscopic, thermal and antitumor investigations of sulfasalazine drug in situ complexation with alkaline earth metal ions |
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| Authors: | Refat Moamen S Mohamed Soha F |
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| Institution: | aDepartment of Chemistry, Faculty of Science, Port Said, Port Said University, Egypt;bDepartment of Chemistry, Faculty of Science, Taif University, 888 Taif, Saudi Arabia;cDepartment of Chemistry, Faculty of Science, Zagazig University, Egypt |
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| Abstract: | The complexes of sulfasalazine (H3Suz) with some of alkaline metals Mg(II), Ca(II), Sr(II) and Ba(II) have been investigated. Sulfasalazine complexes were synthesized and characterized by spectroscopic tools; infrared spectra, electronic and mass spectra. The IR spectra of the prepared complexes were suggested that the H3Suz behaves as a bi-dentate ligand through the carboxylic and phenolic groups. The molar conductance measurements gave an idea about the non-electrolytic behavior of the H3Suz complexes. The thermal decomposition processes for metal(II) complexes of H3Suz viz: M(HSuz)(H2O)4] (where M = Mg(II), Ca(II), Sr(II) or Ba(II)) have been accomplished on the basis of TG/DTG and DTA studies, and the formula conforms to the stoichiometry of the complexes based on elemental analysis. The kinetic analyses of the thermal decomposition were studied using the Coats–Redfern and Horowitz–Metzger equations. The antitumor and antimicrobial activities of the H3Suz and their alkaline metal(II) complexes were evaluated. |
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| Keywords: | Infrared spectra Electronic spectrum Thermal analysis Sulfasalazine Antitumor and antimicrobial activities |
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