The determination of lead in blood using isotope dilution inductively coupled plasma mass spectrometry |
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Authors: | K. E. Murphy and P. J. Paulsen |
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Affiliation: | (1) National Institute of Standards and Technology, 20899 Gaithersburg, MD, USA |
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Abstract: | Isotope dilution inductively coupled plasma mass spectrometry (ID-ICP-MS) was applied to the certification of Pb in four levels of NIST blood SRM, 955a. This standard reference material (SRM) represents a significant improvement over the previous blood reference material and will greatly aid method development. The lowest level, 47.76 ng/g Pb was determined with analysis uncertainty (95% CI, ID-ICP-MS uncertainties) of less than 1% and the highest level, 517.9 ng/g Pb to 0.3%. Uncertainty in the lowest level was due to sample inhomogeneity and variability in the analytical blank as the RSD on ratio measurements was typically better than 0.2%. Properly applied isotope dilution coupled with careful isotope ratio measurements on the ICP-MS offers precision and accuracy for blood Pb analyses beyond what is currently obtainable with routine methods. |
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