Water-soluble nonstoichiometric polyelectrolyte complexes of modified chitosan |
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Authors: | V A Izumrudov I F Volkova E S Grigoryan M Yu Gorshkova |
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Institution: | (1) Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt |
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Abstract: | A modified polysaccharide that, in each deacetylated unit, carries a functional secondary amino group and a quaternized amino
group that provides a positive charge and solubility to the polymer throughout the pH range is prepared by the alkylation
of primary amino groups of chitosan with glycidyltrimethylammonium chloride. The mixing of modified chitosan solutions with
solutions of polystyrenesulfonate or polymethacrylate anions in neutral solutions gives rise to negatively charged nonstoichiometric
polyelectrolyte complexes soluble and stable under physiological conditions. The effects of pH, ionic strength, the degree
of polymerization, the nature of the lyophilizing polyanion, and the charge-to-charge ratio of components on the boundaries
of existence of soluble complexes are ascertained. The collected experimental data may serve as a basis for designing biocompatible
and biodegradable means useful for the delivery of genetic material and drugs to living cells. |
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Keywords: | |
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