A simple method for labelling proteins with211At via diazotized aromatic diamine |
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| Authors: | G Wunderlich S Fischer R Dreyer W -G Franke |
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| Institution: | (1) Clinic for Nuclear Medicine, Medical Academy  Carl Gustav Carus , Fetscherstr. 74, DDR-8019 Dresden, Germany;(2) Department of Chemistry, Technical University, Mommsenstr. 13, DDR-8027 Dresden, Germany |
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| Abstract: | A simple and rapid method for labelling proteins with211At by means of a 1,4-diaminobenzene link is described. 1,4-diaminobenzene is transformed into the diazonium salt and subsequently reactions of both211At and proteins with the diazonium salt take place simultaneously. For possibly high yields of astatized protein an appropriate temperature of 273 K was found. The results demonstrate the difference between the reaction mechanisms of iodine and astatine with proteins. |
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