| Design,Synthesis and Antifungal Activity of Novel Triazole Derivatives |
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| 引用本文： | ChunQuanSHENG WanNianZHANG HaiTaoJI YunLongSONG. Design,Synthesis and Antifungal Activity of Novel Triazole Derivatives[J]. 中国化学快报, 2004, 15(4): 404-407 |
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| 作者姓名： | ChunQuanSHENG WanNianZHANG HaiTaoJI YunLongSONG |
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| 作者单位： | SchoolofPharmacy,SecondMilitaryMedicalUniversity,Shanghai200433 |
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| 摘 要： | Twenty-one 1-(1H-1,2,4-triazolyl)-2-(2,4-diflurophenyl)-3-(4-substituted-1-piperazinyl)-2-propanol derivatives were designed and synthesized,on the basis of the active site of lanosterol 14α-demethylase.In vitro antifungal activities showed that some of the target compounds had higher antifungal activity and broader antifungal spectrum than fluconazole.
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| 关 键 词： | 抗真菌 三唑派生物 合成 设计 |
Design,Synthesis and Antifungal Activity of Novel Triazole Derivatives |
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| Chun Quan SHENG,Wan Nian ZHANG,Hai Tao JI,Yun Long SONG,Min ZHANG,You Jun ZHOU,Jia Quo LU,Ju ZHUSchool of Pharmacy,Second Military Medical University,Shanghai. Design,Synthesis and Antifungal Activity of Novel Triazole Derivatives[J]. Chinese Chemical Letters, 2004, 15(4): 404-407 |
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| Authors: | Chun Quan SHENG Wan Nian ZHANG Hai Tao JI Yun Long SONG Min ZHANG You Jun ZHOU Jia Quo LU Ju ZHUSchool of Pharmacy Second Military Medical University Shanghai |
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| Affiliation: | Chun Quan SHENG,Wan Nian ZHANG,Hai Tao JI,Yun Long SONG,Min ZHANG,You Jun ZHOU,Jia Quo LU,Ju ZHUSchool of Pharmacy,Second Military Medical University,Shanghai 200433 |
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| Abstract: | |
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| Keywords: | Antifungal triazole synthesis. |
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