| Novel Analogues of a-Terthienyl, Thienyl 1, 3, 4-Thia(oxa)diazoles as Potential Photoactivated Insecticides: Synthesis and Bioactivity |
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| 作者姓名： | Li Gang LIU Yu Fang XU Xu Hong QIAN * Qing Chun HUANG Institute of Pesticides & Pharmaceuticals East China University of Science and Technology Shanghai State Key Laboratory of Fine Chemicals Dalian University of Technology Dalian Shanghai Key Lab of Chemical Biology Shanghai |
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| 作者单位： | Li Gang LIU1，3，Yu Fang XU1，3，Xu Hong QIAN2 *，Qing Chun HUANG1，3 1Institute of Pesticides & Pharmaceuticals，East China University of Science and Technology，Shanghai 200237 2State Key Laboratory of Fine Chemicals，Dalian University of Technology，Dalian 116012 3Shanghai Key Lab of Chemical Biology，Shanghai 200237 |
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| 摘 要： | a-Terthienyl (aT) is a phototoxic compound originated from the marigold Tagetes eretra1. The aT and its analogues have been widely used for photodynamic killing of insects, in photodynamic therapy for dermatophytes, and in human immunodeficiency virus (HIV)2. The phototoxicity of aT and its derivatives are attributed to their triplet states that easily generate a reactive oxygen species (ROS). Many of the biomolecules and enzymes are targets of these ROS, such as DNA in vitro and in v…
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Novel Analogues of a-Terthienyl, Thienyl 1, 3, 4-Thia(oxa)diazoles as Potential Photoactivated Insecticides: Synthesis and Bioactivity |
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| Li Gang LIU,,Yu Fang XU,,Xu Hong QIAN *,Qing Chun HUANG, Institute of Pesticides & Pharmaceuticals,East China University of Science and Technology,Shanghai State Key Laboratory of Fine Chemicals,Dalian University of Technology,Dalian Shanghai Key Lab of Chemical Biology,Shanghai .Novel Analogues of a-Terthienyl, Thienyl 1, 3, 4-Thia(oxa)diazoles as Potential Photoactivated Insecticides: Synthesis and Bioactivity[J].Chinese Chemical Letters,2004(1). |
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| Authors: | Li Gang LIU Yu Fang XU Xu Hong QIAN Qing Chun HUANG |
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| Institution: | Li Gang LIU1,3,Yu Fang XU1,3,Xu Hong QIAN2 *,Qing Chun HUANG1,3 1Institute of Pesticides & Pharmaceuticals,East China University of Science and Technology,Shanghai 200237 2State Key Laboratory of Fine Chemicals,Dalian University of Technology,Dalian 116012 3Shanghai Key Lab of Chemical Biology,Shanghai 200237 |
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| Abstract: | Novel 1, 3, 4-thia(oxa)diazoles containing thienyl groups were synthesized. Analogous to the naturally-occurring compound, a-terthienyl, they can be photosensitized by ultraviolet light and showed phototoxicities against the 2nd instar larvae of southern armyworm (Pseudaletia separata Walker), they also showed photocleavage action to pBR322 DNA. |
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| Keywords: | Thiadiazoles oxadiazoles a-terthienyl phototoxic |
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