Cyclocondensation of 2-iodobenzaldehyde with benzamidines catalyzed by copper(I) iodide: a route to 2-arylquinazolines |
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| Authors: | A V Vypolzov D V Dar’in S G Ryazanov P S Lobanov |
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| Institution: | (1) Saint Petersburg State University, Saint Petersburg, 198504, Russia; |
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| Abstract: | The reaction of benzamidines with 2-bromo- and 2-iodobenzaldehydes catalyzed by the CuI/L-proline system has been studied.
Reaction with 2-iodobenzaldehyde leads to the formation of quinazolines in good yield. 2-Bromobenzaldehyde forms 2-arylquinazolines
in low yield due to the competing reaction involving two molecules of amidine leading to a dihydrotriazine. |
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