Determination of betamethasone sodium phosphate in pharmaceuticals by potentiometric membrane sensor based on its lidocaine ion pair |
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Authors: | M. Giahi O. Marvi F. Safari B. Chahkandi |
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Affiliation: | 1. Department of Chemistry, Faculty of Science, Lahijan Branch, Islamic Azad University, Lahidjan, Iran 2. Department of Chemistry, Faculty of Science, Payam Noor University (PUN), 19395-3697, Tehran, I.R. of Iran 3. Behvazan Pharmaceutical Ebensina Street, Industrial City, Rasht, Iran 4. Department of Chemistry, Shahrod Branch, Islamic Azad University Shahrod, Shahrood, Iran
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Abstract: | Betamethasone sodium phosphate (BMNaP) has been employed as an electroactive material in the design of an ion-selective electrode (ISE). The electrode incorporates PVC membrane with betamethasone sodium phosphate-lidocaine ion pair complex. The influences of membrane composition, temperature, pH of the test solution, and the interfering ions on the electrode performance were investigated. The sensor exhibits a Nernstian response for betamethasone sodium phosphate ions over a relatively wide concentration range (1.0 × 10?1 to 1.0 × 10?5 M) with a slope of 28.4 ± 0.9 mV per decade at 25°C. It can be used in the pH range 4.0–10.0. The isothermal temperature coefficient of this electrode amounted to ?0.0008 V/°C. The membrane sensor was successfully applied to the determination of betamethasone sodium phosphate in pharmaceutical products. |
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