Efficient Hyperpolarization of U‐13C‐Glucose Using Narrow‐Line UV‐Generated Labile Free Radicals |
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| Authors: | Dr. Andrea Capozzi M. Sc. Saket Patel M. Sc. Christine Pepke Gunnarsson Dr. Irene Marco‐Rius Dr. Arnaud Comment Dr. Magnus Karlsson Dr. Mathilde H. Lerche Dr. Olivier Ouari Prof. Jan Henrik Ardenkjær‐Larsen |
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| Affiliation: | 1. http://www.hypermag.dtu.dk 0000-0002-2306-9049 Center for Hyperpolarization in Magnetic Resonance, Department of Electrical Engineering, Technical University of Denmark, Building 349, 2800 Kgs Lyngby, Denmark;2. Institut de Chimie Radicalaire, Aix-Marseille Université, CNRS, ICR UMR 7273, 13397 Marseille Cedex 20, France;3. Center for Hyperpolarization in Magnetic Resonance, Department of Electrical Engineering, Technical University of Denmark, Building 349, 2800 Kgs Lyngby, Denmark;4. Cancer Research (UK) Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, United Kingdom;5. General Electric Healthcare, Chalfont St Giles, Buckinghamshire, HP8 4SP UK |
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| Abstract: | Free radicals generated by UV‐light irradiation of a frozen solution containing a fraction of pyruvic acid (PA) have demonstrated their dissolution dynamic nuclear polarization (dDNP) potential, providing up to 30 % [1‐13C]PA liquid‐state polarization. Moreover, their labile nature has proven to pave a way to nuclear polarization storage and transport. Herein, differently from the case of PA, the issue of providing dDNP UV‐radical precursors (trimethylpyruvic acid and its methyl‐deuterated form) not involved in any metabolic pathway was investigated. The 13C dDNP performance was evaluated for hyperpolarization of [U‐13C6,1,2,3,4,5,6,6‐d7]‐d ‐glucose. The generated UV‐radicals proved to be versatile and highly efficient polarizing agents, providing, after dissolution and transfer (10 s), a 13C liquid‐state polarization of up to 32 %. |
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| Keywords: | Glucose Hyperpolarisierung NMR-Spektroskopie Radikale |
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