Aqueous Stable Gold Nanostar/ZIF‐8 Nanocomposites for Light‐Triggered Release of Active Cargo Inside Living Cells |
| |
Authors: | Carolina Carrillo‐Carrin Raquel Martínez María F NavarroPoupard Beatriz Pelaz Ester Polo Ana Arenas‐Vivo Alessandro Olgiati Pablo Taboada Mahmoud G Soliman Úrsula Cataln Sara Fernndez‐Castillejo Rosa Sol Wolfgang J Parak Patricia Horcajada Ramon A Alvarez‐Puebla Pablo delPino |
| |
Institution: | Carolina Carrillo‐Carrión,Raquel Martínez,María F. Navarro?Poupard,Beatriz Pelaz,Ester Polo,Ana Arenas‐Vivo,Alessandro Olgiati,Pablo Taboada,Mahmoud G. Soliman,Úrsula Catalán,Sara Fernández‐Castillejo,Rosa Solà,Wolfgang J. Parak,Patricia Horcajada,Ramon A. Alvarez‐Puebla,Pablo del?Pino |
| |
Abstract: | A plasmonic core–shell gold nanostar/zeolitic‐imidazolate‐framework‐8 (ZIF‐8) nanocomposite was developed for the thermoplasmonic‐driven release of encapsulated active molecules inside living cells. The nanocomposites were loaded, as a proof of concept, with bisbenzimide molecules as functional cargo and wrapped with an amphiphilic polymer that prevents ZIF‐8 degradation and bisbenzimide leaking in aqueous media or inside living cells. The demonstrated molecule‐release mechanism relies on the use of near‐IR light coupled to the plasmonic absorption of the core gold nanostars, which creates local temperature gradients and thus, bisbenzimide thermodiffusion. Confocal microscopy and surface‐enhanced Raman spectroscopy (SERS) were used to demonstrate bisbenzimide loading/leaking and near‐IR‐triggered cargo release inside cells, thereby leading to DNA staining. |
| |
Keywords: | Metallorganische Gerü ste Nanocomposites Thermoplasmonik Wirkstofffreigabe ZIF-8 |
|
|