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Asymmetric Alkenylation of Enones and Imines Enabled by A Highly Efficient Aryl to Vinyl 1,4‐Rhodium Migration |
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| Authors: | Shu‐Sheng Zhang Tian‐Jiao Hu Meng‐Yao Li Yi‐Kang Song Xiao‐Di Yang Chen‐Guo Feng Guo‐Qiang Lin |
| Abstract: | The asymmetric rhodium‐catalyzed alkenylation of enones and imines with arylboronic acids has been developed. A highly controllable aryl to vinyl 1,4‐rhodium migration is the key step. Stereodefined vinyl moieties were installed in excellent enantioselectivies for most examined examples. DFT calculations reveal that the driving force of this rhodium migration is a kinetically favored process. |
| Keywords: | Alkenylierung Asymmetrische Katalyse C-H-Funktionalisierung Metall-Migration Rhodium |