Dearomatization of 3‐Nitroindoles by a Phosphine‐Catalyzed Enantioselective [3+2] Annulation Reaction |
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Authors: | Kaizhi Li,Th o P. Gon alves,Kuo‐Wei Huang,Yixin Lu |
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Affiliation: | Kaizhi Li,Théo P. Gonçalves,Kuo‐Wei Huang,Yixin Lu |
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Abstract: | The dearomatization of 3‐nitroindoles through a chiral‐phosphine‐mediated [3+2] annulation reaction is described. This method makes use of readily available 3‐nitroindoles as an aromatic feedstock and rapidly delivers a wide range of cyclopentaindoline alkaloid scaffolds in a highly enantioselective manner. Notably, phosphine‐triggered cyclization has not been utilized previously in a dearomatization process. |
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Keywords: | [3+2]-Anellierung Cyclopentaindoline Dearomatisierung Nitroindole Organokatalyse |
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