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Development of a Universal Fluorescent Probe for Gram‐Positive Bacteria
Authors:Haw‐Young Kwon  Xiao Liu  Eun Gyeong Choi  Jung Yeol Lee  So‐Young Choi  Jun‐Young Kim  Lu Wang  Sung‐Jin Park  Beomsue Kim  Yong‐An Lee  Jong‐Jin Kim  Nam Young Kang  Young‐Tae Chang
Abstract:The rapid and sensitive classification of bacteria is the first step of bacterial community research and the treatment of infection. Herein, a fluorescent probe BacGO is presented, which shows the best universal selectivity for Gram‐positive bacteria among known probes with a minimum staining procedure for sample detection and enrichment of the live bacteria. BacGO could also be used to assess of the Gram status in the bacterial community from wastewater sludge. Furthermore, BacGO could sensitively and selectively detect a Gram‐positive bacterial infection, not only in vitro but also using an in vivo keratitis mouse model. BacGO provides an unprecedented research tool for the study of dynamic bacterial communities and for clinical application.
Keywords:Biologische Bildgebung  Borsä  ure  Fluoreszenzsonden  Gram-positive Bakterien  Struktur-Aktivitä  ts-Beziehungen
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