Enantioselective Palladium‐Catalyzed Cross‐Coupling of α‐Bromo Carboxamides and Aryl Boronic Acids

We herein report an enantioselective palladium‐catalyzed cross‐coupling between α‐bromo carboxamides and aryl boronic acids, generating a series of chiral α‐aryl carboxamides in good yields and excellent enantioselectivities. The development of a chiral P,P=O ligand was critical in overcoming the second transmetalation issue and allows the first asymmetric palladium‐catalyzed coupling of α‐bromo carbonyl compounds.