Tandem migration-carboalkoxylation of o-isocyanophenyl acetals leading to benzoxazoles |
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| Authors: | Okitsu Takashi Nagase Kenta Nishio Nobuhiko Wada Akimori |
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| Affiliation: | Department of Organic Chemistry for Life Science, Kobe Pharmaceutical University, 4-19-1, Motoyamakita-machi, Kobe 658-8558, Japan. |
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| Abstract: | An efficient approach to benzoxazoles via tandem migration-carboalkoxylation of o-isocyanophenyl acetals has been developed. Both a Lewis acid and base are essential for this reaction, and the BF(3)·OEt(2)/2,4,6-collidine combination is the best choice for cooperative transformation. |
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