Captured at last: a catalyst-substrate adduct and a Rh-dihydride solvate in the asymmetric hydrogenation by a Rh-monophosphine catalyst |
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| Authors: | Gridnev Ilya D Alberico Elisabetta Gladiali Serafino |
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| Institution: | Department of Applied Chemistry, Graduate School of Science and Engineering, Tokyo Institute of Technology 2-12-1 O-okayama, Tokyo 152-8552, Japan. gridnev.i.aa@m.titech.ac.jp |
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| Abstract: | The mechanism of asymmetric hydrogenation catalyzed by Rh(NBD)((R)-PhenylBinepine)(2)]SbF(6)1 has been studied by NMR experiments and DFT computations. Either the low-temperature hydrogenation of the catalyst-substrate adduct 4 or the reaction of solvate dihydride 6 with MAC produced the hydrogenation product with over 99% ee (S). |
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