An efficient ultrasound-promoted method for the synthesis of bis(indole) derivatives |
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Affiliation: | Department of Chemistry, Yazd University, P.O. Box 89195–741, Yazd, Iran |
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Abstract: | In this paper, the reaction of indole with electron-deficient alkenes in aqueous media is reported. This procedure allows the synthesis of bis(indole) derivatives in good to high yields at 90 °C under silent and ultrasound irradiation conditions. Short reaction times and high yields of desired products are the main advantages of the presented procedure. This reaction catalyzed by 12-tungstophosphoric acid is operationally simple and considers environmental aspects by avoiding toxic catalysts and solvents. |
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Keywords: | Aqueous media Bis(indole) Heteropolyacids Michael reactions Oxidative dehydrogenation Ultrasonication |
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