A ruthenium(II) complex with the propionate ion: Synthesis,characterization and cytotoxic activity |
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| Institution: | 1. Instituto de Química, Universidade Federal de Uberlândia, CP 593, CEP 38400-902, Uberlândia (MG), Brazil;2. Departamento de Química, Universidade Federal de São Carlos, CP 676, CEP 13565-905, São Carlos (SP), Brazil;3. Instituto de Química de São Carlos, Universidade de São Paulo, CP 780, CEP 13566-590, São Carlos (SP), Brazil;4. Universidade de Franca, CEP 14404-600, Franca(SP), Brazil;5. Instituto de Ciências Biológicas, Universidade Federal de Goiás, CP 2425-0, CEP 74690-970, Goiânia (GO), Brazil |
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| Abstract: | The complex Ru(η2-O2CCH2CH3)(dppe)2]PF6 (dppe = 1,2-bis(diphenylphosphino)ethane) was prepared and characterized by elemental analysis, spectroscopic techniques, X-ray crystallography, HRESIMS and HRESIMS/MS. The characterization data are consistent with a cis arrangement for the dppe ligands and a bidentate coordination of the propionate ligand through carboxylate oxygens. Cytotoxicity assays were carried out on human and murine cancer and normal cell lines. In general, the Ru(η2-O2CCH2CH3)(dppe)2]PF6 complex was more cytotoxic than both its precursor cis–RuCl2(dppe)2] and the reference metallodrug cisplatin. The best results against the HepG2 human tumour cell line and S180 murine tumour cell line were found with IC50 values of 6.5 ± 0.2 and 0.18 ± 0.03 μM, respectively. |
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| Keywords: | Ruthenium Biological activity Mass spectrometry Carboxylate ligands Phosphane ligands X-Ray diffraction |
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