O-苯甲酰吡啶甲醛肟衍生物的合成及其季铵化反应

为了解除人畜常被杀虫剂有机磷酸酯所致的中毒症状,文献曾报道一系列乙酰胆碱酯酶复能剂的研究和机理探讨^1],其中用于临床的有吡啶2-甲醛肟碘或氯甲烷盐等.ciba公司和schnekenburger等曾先后合成若干肟醚类和吡啶N-氧化物甲醛肟酯类季铵盐.作者设想合成若干吡啶甲醛肟酯季铵盐^2,3].

Synthesis of O benzoyl Pyridine-2-and 4-Aldoxime Derivatives and Their Quaternizations

O-Benzoyl-,O-( 3,4,5-trimethoxybenzoyl)-, O-( 4-chloro-benzoyl)-and O-(4-nitrobenzoyl)- pyridine-2- and 4-aldoximes were synthesized conveniently from the acylation of pridine-2-and 4-aldoximes with corresponding aroyl chlorides by a modified procedure. From the quaterniza-tion of O-benzoyl, O-(3, 4, 5-trimethoxy-benzoyl)-and O-(4-chlorobenzoyl) -piridine-4-aldoximes with methyl iodide the normal methiodides were obtained, but during the quaternization of the corresponding derivatives of 2-aldoximes the β-elimination also occurred so that only the abnormal product of 2-cyanopiridine methiodide was formed. Both O-( 4-nitroben-zoyl )-piridine-2- and 4-aldoximes reacted not with methyl iodide.