Thermal characterization of raw material pentoxifylline using thermoanalytical techniques and Pyr-GC/MS |
| |
| Authors: | Agna Hélia de Oliveira Elisana Afonso de Moura Márcia Ferraz Pinto José Valdilânio Virgulino Procópio Valmir Gomes de Souza Fábio Santos de Souza Rui Oliveira Macêdo |
| |
| Institution: | 1.Department of Pharmaceutical Sciences, Postgraduate Program in Pharmaceutical Sciences,Federal University of Pernambuco,Recife,Brazil;2.Department of Pharmaceutical Sciences, Unified Laboratories of Pharmaceutical Development and Assays,Federal University of Paraíba, Campus I,Jo?o Pessoa,Brazil |
| |
| Abstract: | This work studied the thermal characterization of the pentoxifylline raw material through thermoanalytical techniques (TG,
DSC, DSC-photovisual) and analysis of degradation products by Pyr-GC/MS. The picture obtained with DSC-photovisual showed
the total vaporization of pentoxifylline at 230.0 °C. The TG dynamical curve presented only one step for the loss of mass
evidencing to be a kinetic process of zero order reaction. The pyrograms obtained for pentoxifylline sample in the solid state
and solution in the temperatures of 250.0, 300.0, and 400.0 °C, showed only one peak identifying the pentoxifylline. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
