Abstract: | Abstract In the paper, the deriviation algebras of the associative algebras of the one-variable (resp. multivariable) q-differential operators and of their corresponding Lie algebras are determined. The completeness of the derivation algebras of the algebras of q-differential operators is also discussed. Finally, we calculate H 2(𝒟 q (n)?, C) for n ≥ 1, as well as H 2(g l n (𝒟 q ), C) under the assumption that q is transcendental over the rational numbers field Q. |