Pyrimidines. XVII. I-(Tetrahydro-2-pyranyl)cytosine, -uracil, -thymine and related compounds

In view of the reported biological activities of antibiotics Amicetin and Blasticidin S, 1-(tetrahydro-2-pyranyl)cytosine, -uracil, -thymine and related compounds were synthesized. These compounds were prepared by the Hilbert-Johnson method from 2-chloro-tetrahydropyran and corresponding 2,4-dimethoxypyrimidines.