新型酰胺金属配合物的热力学稳定性研究

酰胺在自然界中广泛存在，生物体内很多金属酶中的酰胺都参与了金属配位，文献表明，配位的金属离子可以促进酰胺的去质子化，去质子后的酰胺氮原子是一种良好的电子授体，当前对酰胺配体的研究已有报道，为模拟抗癌药物博莱霉素，Rowland等合成了一个新型五齿酰胺配体：N，N-双(2-吡啶甲基)胺-N-乙基-2-吡啶-2-甲酰胺(L)，并对其三价铁配合物的单晶结构进行了表征，实验证明此配体在配合物中的配位环境和化学性质与博莱霉素非常相似。

Thermodynamic Studies on a New Type of Carboxamide Metal Complexes

N,N-Bis(2-pyridylmethyl)-amine-N-ethyl-2-pyridine-2-carboxamide was synthesized and characterized according to the literature. At 25 ℃, I=0.1 mol/L KNO3, the stability constants of the binary system formed by the ligand with metal ions in ethanol aqueous solution were studied by pH potentiometric titration and the appropriate structures with respect to the titration species were proposed. The results show that the stability order of divalent metals binding to the ligand is CoCu