Solid-phase synthesis of pyrazolopyridines from polymer-bound alkyne and azomethine imines |
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| Authors: | Harju Kirsi Kylänlahti Irene Paananen Timo Polamo Mika Nielsen John Yli-Kauhaluoma Jari |
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| Affiliation: | Division of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Helsinki, Finland. |
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| Abstract: | Study was made of the 1,3-dipolar cycloaddition of polymer-bound alkynes to azomethine imines generated in situ from N-aminopyridine iodides. Aromatization of the cycloadducts gives polymer-bound pyrazolopyridines that can be released from the resin as carboxylic acids with trifluoroacetic acid or as methyl esters with sodium methoxide. |
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