Synthesis and in vitro biological evaluation of farnesylthiosalicylic acid derivatives as anti-tumor carcinoma agents |
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| Authors: | Yong Linga You An Xiaob Guang Tong Chena Dong Geng Wanga Yu Qin Lia Xin Yang Wanga Heng Zhengc a |
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| Institution: | Department of Pharmacy, School of Medical, Nantong University, Nantong 226001, China ; Medicinal College, Anhui College of Traditional Chinese Medicine, Hefei 230031, China ; Department of Bioinformatics, College of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China |
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| Abstract: | Novel farnesylthiosalicylic acid (FTA) derivatives 5a?m with different substituted 1,3,4-thiadiazoles were synthesized. Compounds 5b, 5c, 5e and 5f displayed anti-tumor activities superior to FTA in most cancer cells tested. Furthermore, 5e induced tumor cell apoptosis, which was accompanied by lower Bcl-2 expression, but with higher Bax and caspase 3 expression activities in cancer cells. |
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| Keywords: | Synthesis Farnesylthiosalicylic acid 1 3 4-Thiodiazole Anti-tumor agents Cytotoxic activities Cell apoptosis |
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