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Efficient synthesis of 4(3H)-quinazolinones using a soluble polymeric support |
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| Authors: | Chang Xie Hong Xia Li Ming Guo Liu Ming Wu Ding |
| Abstract: | 4(3H)-Quinazolinones have been synthesized from poly(ethylene glycol) (PEG) supported aza-Wittig reaction. 2-Dialkylamino-4(3H)-quinazolinones 6 were synthesized efficiently by reaction of secondary amine with PEG-supported carbodiimides 4, whichwere obtained from aza-Wittig reaction of PEG-supported iminophosphoranes 3 with isocyanates.?2008 Ming Wu Ding. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved. |
| Keywords: | 4(3H)-Quinazolinone Poly(ethylene glycol) supported Aza-Wittig reaction Carbodiimide Iminophosphorane |
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