Synthesis of dihydrobenzoimidazo[2,1-a]isoquinolines |
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| Authors: | Meng-Yang Chang Ming-Hao WuYeh-Long Chen |
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| Affiliation: | Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung 807, Taiwan |
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| Abstract: | A one-pot protocol toward several substituted 5,6-dihydrobenzo[4,5]imidazo[2,1-a]isoquinolines 1 starting with 2-allylbenzaldehydes 2 was described. The process was carried out the one-pot condensation/hydroamination reaction of substituted 2-allylbenzaldehydes 2 with 1,2-diaminobenzenes 3 in refluxing toluene in good yields. Skeleton 2 was prepared via one-pot ortho-metalative PhBCl2-mediated double alkylation of hydroxybenzaldehyde 4 with LDA in moderate yields. |
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| Keywords: | Dihydrobenzo[4,5]imidazo[2,1-a]isoquinolines Metalation Hydroamination One-pot tandem reaction |
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