Synthesis of tetra-substituted pyrroles, a potential phosphodiesterase 4B inhibitor, through nickel(II) chloride hexahydrate catalyzed one-pot four-component reaction |
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| Authors: | Abu T Khan Mohan LalPrasanta Ray Bagdi R Sidick BashaParameswaran Saravanan Sanjukta Patra |
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| Institution: | a Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781 039, India
b Department of Biotechnology, Indian Institute of Technology Guwahati, Guwahati 781 039, India |
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| Abstract: | A wide variety of tetra-substituted pyrrole derivatives were synthesized through one-pot four-component condensation reaction of aromatic aldehydes, benzylamines, β-ketoesters, and nitroalkanes in the presence of 10 mol % NiCl2·6H2O in good yields. Some of them exhibit properties as potential inhibitors of phosphodiesterase 4B (PDE4B) through docking studies. |
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| Keywords: | Multicomponent reactions β-Ketoesters Nickel(II) chloride hexahydrate Tetra-substituted pyrroles Docking studies Phosphodiesterase 4B inhibitor |
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