Molecular weight determination of hypromellose acetate succinate (HPMCAS) using size exclusion chromatography with a multi-angle laser light scattering detector |
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Authors: | Fukasawa Miyuki Obara Sakaé |
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Affiliation: | Specialty Chemicals Research Center, Shin-Etsu Chemical Co. Ltd., 28-1 Nishifukushima, Kubiki-mura, Nakakubiki-gun, Niigata 942-8601, Japan. miyuki-fukasawa@shinetsu.jp |
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Abstract: | The molecular weight of hypromellose acetate succinate (HPMCAS), a polymer used for enteric coating, was determined by means of size exclusion chromatography with a multi-angle laser light scattering detector. The weight-average molecular weight (Mw) of several lots and grades ranged approximately from 17000 to 20000, and the number-average molecular weight (Mn) was around 13000. The inter-day precision of measurement, in terms of the coefficient of variation, was less than 5%. |
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