Synthesis of Xenbucin using Suzuki reaction catalyzed by Pd/C in water |
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| Authors: | Noora Kuuloja Tuula Kylmälä Youjun Xu Robert Franzén |
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| Affiliation: | (1) Department of Chemistry and Bioengineering, Tampere University of Technology, 33101 Tampere, Finland;(2) School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, 110016, China |
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| Abstract: | Xenbucin 1, an analgesic drug, was synthesized in 4 steps using two different routes. The biaryl fragment could successfully be produced via a Pd/C catalysed Suzuki coupling in water using sodium tetraphenylborate as a phenylation reagent. Overall yields of the routes were 36% and 59%, respectively.  |
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| Keywords: | Xenbucin Suzuki coupling Pd/C Sodium tetraphenylborate NSAID |
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