Synthesis of Xenbucin using Suzuki reaction catalyzed by Pd/C in water |
| |
| Authors: | Noora Kuuloja Tuula Kylmälä Youjun Xu Robert Franzén |
| |
| Institution: | (1) Department of Chemistry and Bioengineering, Tampere University of Technology, 33101 Tampere, Finland;(2) School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, 110016, China |
| |
| Abstract: | Xenbucin 1, an analgesic drug, was synthesized in 4 steps using two different routes. The biaryl fragment could successfully be produced
via a Pd/C catalysed Suzuki coupling in water using sodium tetraphenylborate as a phenylation reagent. Overall yields of the
routes were 36% and 59%, respectively.
 |
| |
| Keywords: | Xenbucin Suzuki coupling Pd/C Sodium tetraphenylborate NSAID |
| 本文献已被 SpringerLink 等数据库收录！ |
|
