| Synthesis of N-Glycyl-2,3,4,6-tetra-O-benzyl-1,5-dideoxy-1,5- imino-D-glucitol |
| |
| 作者姓名： | XU Ming
WANG Xue-Feng
LI Zhong-Jun
LI Hui |
| |
| 作者单位： | XU,Ming（Research Institute of Chemical Defence, Beijing 102205;Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100083）
WANG,Xue-Feng（Institute of Chemical Defence, Beijing 102205）
LI,Zhong-Jun（Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100083）
LI,Hui（Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100083） |
| |
| 基金项目： | Project supported by the Post-doctor Foundation of China in 2001. |
| |
| 摘 要： | 1-Deoxynojirimycin (1,5-dideoxy-1,5-imino-D-glucitol, DNJ) and its derivatives have been found to have a number of biological activities, such as anti-HIV, anticancer, anti-diabetic, etc.1] N-Hydroxylethyldeoxynojirimycin (Miglitol)has been used as a drug for treating diabetic. N-Butyl-1-deoxynojirimycin (NB-DNJ) has show potent anti-HIV-1 and HIV-2 activity without cytotoxicity.2] Recently, NB-DNJ has been approved for clinical trials as a potential therapy for some glycosphingolipid (GSL) lysosomal storage diseases, which belong to a group of severe and fatal human diseases3]Therefore, it is very significant to study N-substituted compounds of DNJ.
|
Synthesis of N-Glycyl-2,3,4,6-tetra-O-benzyl-1,5-dideoxy-1,5- imino-D-glucitol |
| |
| XU,Ming,WANG,Xue-Feng,LI,Zhong-Jun,LI,Hui.Synthesis of N-Glycyl-2,3,4,6-tetra-O-benzyl-1,5-dideoxy-1,5- imino-D-glucitol[J].Chinese Journal of Organic Chemistry,2004,24(Z1):1. |
| |
| Authors: | XU Ming WANG Xue-Feng LI Zhong-Jun LI Hui |
| |
| Abstract: | 1-Deoxynojirimycin (1,5-dideoxy-1,5-imino-D-glucitol, DNJ) and its derivatives have been found to have a number of biological activities, such as anti-HIV, anticancer, anti-diabetic, etc.1] N-Hydroxylethyldeoxynojirimycin (Miglitol)has been used as a drug for treating diabetic. N-Butyl-1-deoxynojirimycin (NB-DNJ) has show potent anti-HIV-1 and HIV-2 activity without cytotoxicity.2] Recently, NB-DNJ has been approved for clinical trials as a potential therapy for some glycosphingolipid (GSL) lysosomal storage diseases, which belong to a group of severe and fatal human diseases3]Therefore, it is very significant to study N-substituted compounds of DNJ. |
| |
| Keywords: | |
| 本文献已被 万方数据 等数据库收录！ |
|
