Derivatization of amines with chloroformate esters for gas chromatographic analysis |
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| Authors: | N O Ahnfelt P Hartvig K E Karlsson |
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| Institution: | (1) Department of Analytical Pharmaceutical Chemistry, Biomedical Center, University of Uppsala, Box 574, Uppsala, Sweden;(2) Hospital Pharmacy, University Hospital, S-751 23 Uppsala, Sweden |
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| Abstract: | Summary The gas chromatographic analysis of amines after conversion to electron capture sensitive carbamates in two-phase systems has been studied. Hydrophilic compounds, for instance methylamine, are reacted with 2,2,2-trichloro-tert. butyl chloroformate. Quantitation below 10–7 M can be made by thermionic or electron capture detection. A hydrophobic amine, namely N,N-dimethyl-n-octylamine, was derivatized with 2,4,6-tribromophenyl chloroformate with addition of iodide ion to the aqueous phase. The favorable effect of iodide ion as well as the choice of pH and chloroformate ester is discussed.Presented at the  14th International Symposium on Chromatography London, September, 1982 |
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| Keywords: | Gas chromatography Amines Derivatization Chloroformate esters |
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