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Twelve New Seco-Pregnane Glycosides from Cynanchum taihangense
Authors:Yu-Bo Wang  Dan Zhao  Shan-Shan Su  Gang Chen  Hai-Feng Wang  Yue-Hu Pei
Affiliation:1.School of Pharmacy, Jinzhou Medical University, Jinzhou 121001, China;2.School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China;3.Research & Development Center, Zhejiang Xianju Pharmaceutical Co., Ltd., Taizhou 317300, China;4.Key Laboratory of Food Safety Research in Qinghai Province, Xining Customs District, Xining 810003, China
Abstract:For our interest in the potential biologically active and structurally unique steroidal glycosides, continued phytochemical investigation of Cynanchum taihangense was carried out; twelve new seco-pregnane glycosides, cynataihosides I–L (1–4), M-T (7–14), and two known glycosides, glaucoside A (5) and atratcynoside F (6), were isolated from the 95% ethanol extract of Cynanchum taihangense. Two new aglycones were found among compounds 10, 11, 13, and 14. The structures of the glycosides were elucidated based on 1D and 2D NMR spectroscopic data, HR-ESI-MS analysis, and chemical evidence. The cytotoxicity of compounds against three human tumor cell lines (HL-60, THP-1, and PC-3) were evaluated by MTT assay. Compound 11 displayed significant cytotoxicity against THP-1 and PC-3 cell line with IC50 values of 5.08 and 22.75 μm, respectively. Compounds 3 and 14 exhibited moderate and selective cytotoxicity on HL-60 and THP-1 with IC50 values of 17.78 and 16.02 μm, respectively.
Keywords:Cynanchum taihangense, pregnane steroidal glycosides, cynataihoside I–  T, NMR data, cytotoxicity
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