Nucleophilic Functionalization of 2-R-3-Nitropyridines as a Versatile Approach to Novel Fluorescent Molecules |
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| Authors: | Vladislav V. Nikol’ skiy,Mikhail E. Minyaev,Maxim A. Bastrakov,Alexey M. Starosotnikov |
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| Affiliation: | N.D. Zelinsky Institute of Organic Chemistry RAS, Leninsky Prosp. 47, 11991 Moscow, Russia |
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| Abstract: | A number of new 2-methyl- and 2-arylvinyl-3-nitropyridines were synthesized and their reactions with thiols were studied. It was found that 3-NO2 tends to be selectively substituted under the action of sulfur nucleophiles in the presence of another nucleofuge in position 5. Correlations between the substitution pattern and regioselectivity as well as photophysical properties were established. Some synthesized compounds possessed a large Stokes shift. |
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| Keywords: | nitro group, nitropyridines, bis-(het)aryl ethenes, nucleophilic substitution, thiols, UV– Vis spectroscopy |
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