| New Fragmentation Pathways for Cephalosporins by Electrospray Ionization Quadrupole Time-of-flight Mass Spectrometry |
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| 作者姓名： | WANGYing-wu GUJing-kai J.PaulFawcett ZHONGDa-fang ZHOUHui |
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| 作者单位： | [1]ResearchCenterforDrugMetabolism,CollegeofLifeScience,JilinUniversity,Changchun130023,P.R.China [2]SchoolofPharmacy,UniversityofOtago,P.O.Bow913,Dunedin,NewZealand |
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| 基金项目： | SupportedbytheNationalNaturalScienceFoundationofChina(Nos.39930180and30070879). |
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| 摘 要： | Introduction Cephalosporins are antibiotics of β-lactam family. They have a broad spectrum of antibiotic activity due to their ability to inhibit bacterial cell wall synthesis of different Gram-positive and Gram-negative bacteria. Cephalosporins are used orally or parenterally to treat a wide variety of infections throughout the body and are often prescribed to fight penicillin resistant microorganisms.
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| 关 键 词： | 头孢菌素 光谱测定法 分析方法 抗生素 化学结构 药物 |
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