Studies toward the total synthesis of garsubellin A: a concise synthesis of the 18-epi-tricyclic core |
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Authors: | Usuda Hiroyuki Kanai Motomu Shibasaki Masakatsu |
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Institution: | Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. |
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Abstract: | reaction: see text] During studies directed toward the total synthesis of garsubellin A, a concise stereocontrolled synthesis of the 18-epi-tricyclic compound 3 was achieved. Key steps were a one-pot stereoselective construction of the bicyclic lactone 23 followed by a formal migration to the bicyclo3.3.1]nonane-1,3,5-trione and an intramolecular Wacker-type tetrahydrofuran ring formation. |
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