Recent Applications of the Multicomponent Synthesis for Bioactive Pyrazole Derivatives |
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Authors: | Diana Becerra Rodrigo Abonia Juan-Carlos Castillo |
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Affiliation: | 1.Escuela de Ciencias Química, Facultad de Ciencias, Universidad Pedagógica y Tecnológica de Colombia, Avenida Central del Norte, Tunja 150003, Colombia;2.Research Group of Heterocyclic Compounds, Department of Chemistry, Universidad del Valle, A.A. 25360, Cali 76001, Colombia; |
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Abstract: | Pyrazole and its derivatives are considered a privileged N-heterocycle with immense therapeutic potential. Over the last few decades, the pot, atom, and step economy (PASE) synthesis of pyrazole derivatives by multicomponent reactions (MCRs) has gained increasing popularity in pharmaceutical and medicinal chemistry. The present review summarizes the recent developments of multicomponent reactions for the synthesis of biologically active molecules containing the pyrazole moiety. Particularly, it covers the articles published from 2015 to date related to antibacterial, anticancer, antifungal, antioxidant, α-glucosidase and α-amylase inhibitory, anti-inflammatory, antimycobacterial, antimalarial, and miscellaneous activities of pyrazole derivatives obtained exclusively via an MCR. The reported analytical and activity data, plausible synthetic mechanisms, and molecular docking simulations are organized in concise tables, schemes, and figures to facilitate comparison and underscore the key points of this review. We hope that this review will be helpful in the quest for developing more biologically active molecules and marketed drugs containing the pyrazole moiety. |
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Keywords: | multicomponent reactions (MCRs) pyrazole derivatives biological activity medicinal chemistry drug discovery |
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