Synthesis and Antibacterial Evaluation of 1,2,3‐Triazole‐based Quinazolines Using Click Chemistry in the Presence of Salophen Schiff Base Ligand

The reaction of 2‐chloro‐4‐(prop‐2‐ynyloxy)quinazoline or 2‐chloro‐N‐(prop‐2‐ynyl)quinazolin‐4‐amine with aromatic azides in the presence of the salophen Schiff base ligand afforded new derivatives of 1,2,3‐triazole‐based quinazoline scaffold in high‐to‐excellent reaction yields. The main advantage of this procedure is that the toxicity of the copper catalyst used could be decreased to 2 mol% by complexation with the salophen ligand. All the synthesized compounds were screened for their in vitro antibacterial activities against the Gram‐positive and Gram‐negative bacteria using the well‐diffusion method.