| Abstract: | Reported here is a novel dynamic biointerface based on reversible catechol‐boronate chemistry. Biomimetically designed peptides with a catechol‐containing sequence and a cell‐binding sequence at each end were initially obtained. The mussel‐inspired peptides were then reversibly bound to a phenylboronic acid (PBA) containing polymer‐grafted substrate through sugar‐responsive catechol‐boronate interactions. The resultant biointerface is thus capable of dynamic presentation of the bioactivity (i.e. the cell‐binding sequence) by virtue of changing sugar concentrations in the system (similar to human glycemic volatility). In addition, the sugar‐responsive biointerface enables not only dynamic modulation of stem cell adhesion behaviors but also selective isolation of tumor cells. Considering the highly biomimetic nature and biological stimuli‐responsiveness, this mussel‐inspired dynamic biointerface holds great promise in both fundamental cell biology research and advanced medical applications. |
