| Synthesis and Biological Activities of N-Phosphoryl Branched Peptides |
| |
| 引用本文： | Sheng Li CAO1,2,Yu Yang JIANG1,Yu Ping FENG1,Yan Ling NIU1,Yu Fen ZHAO1* 1Key Laboratory of Bioorganic Phosphorus Chemistry,Ministry of Education, Department of Chemistry,Tsinghua University,Beijing 100084 2Department of Chemistry,Capital Normal University,Beijing 100037. Synthesis and Biological Activities of N-Phosphoryl Branched Peptides[J]. 中国化学快报, 2003, 14(4) |
| |
| 作者姓名： | Sheng Li CAO1 2 Yu Yang JIANG1 Yu Ping FENG1 Yan Ling NIU1 Yu Fen ZHAO1* 1Key Laboratory of Bioorganic Phosphorus Chemistry Ministry of Education Department of Chemistry Tsinghua University Beijing 100084 2Department of Chemistry Capital Normal University Beijing 100037 |
| |
| 作者单位： | Sheng Li CAO1，2，Yu Yang JIANG1，Yu Ping FENG1，Yan Ling NIU1，Yu Fen ZHAO1* 1Key Laboratory of Bioorganic Phosphorus Chemistry，Ministry of Education; Department of Chemistry，Tsinghua University，Beijing 100084 2Department of Chemistry，Capital Normal University，Beijing 100037 |
| |
| 基金项目： | This work is supported by Natural Science Foundation of Beijing City (7002006). Elemental analyses were performed by Institute of Chemistry，Chinese Academy of Science. |
| |
| 摘 要： | Much research has shown that some N-phosphoryl peptides are endowed with important biological activities. For instance, Na-(diaryloxyphosphoryl)-L-alanyl-L-prolines are moderate inhibitors of angiotensin converting enzyme and yield highly potent inhibitors when they hydrolyze under physiological condition lossing 1 mol phenol1; Phosphoramido (N-[(a-rhamnopyranosyloxy)hydroxyphosphinyl]-L-Leu-L-Trp) and its analogues have been shown to be inhibitors of endothelin converting enzyme, therefor…
|
Synthesis and Biological Activities of N-Phosphoryl Branched Peptides |
| |
| Sheng Li CAO,Yu Yang JIANG,Yu Ping FENG,Yan Ling NIU,Yu Fen ZHAO. Synthesis and Biological Activities of N-Phosphoryl Branched Peptides[J]. Chinese Chemical Letters, 2003, 14(4) |
| |
| Authors: | Sheng Li CAO Yu Yang JIANG Yu Ping FENG Yan Ling NIU Yu Fen ZHAO |
| |
| Abstract: | A series of N-phosphoryl branched peptides were synthesized by coupling of various N-phosphoryl amino acids to L-Lysine methyl ester, and their structures were confirmed by 31P NMR, 1H NMR, MS and elemental analysis. The results of cell biological tests indicated that compound 1d and 1e obviously inhibited the growth of both K562 and A2780 cells. |
| |
| Keywords: | N-Phosphoryl branched peptide synthesis biological activity apoptosis. |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
