Atropisomeric properties of the dibenzo[b,d]azepin-6-one nucleus |
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| Authors: | Tabata Hidetsugu Akiba Kumi Lee Shoukou Takahashi Hideyo Natsugari Hideaki |
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| Institution: | School of Pharmaceutical Sciences, Teikyo University, 1091-1 Sagamiko, Sagamihara, Kanagawa 229-0195, Japan. |
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| Abstract: | Dibenzob,d]azepin-6-ones (2a,b) were separated by chiral HPLC into the aR- and aS-atropisomers with high stereochemical stability, and methylation at C7 of 2a stereoselectively gave the (aR*,7R*) isomer (4a), which converted to the thermodynamically stable (aS*,7R*) atropisomer (5a) after heating. |
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