| 2-取代氨基-5-吡唑基-1,3,4-噁二唑的合成及生物活性 |
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| 引用本文： | 袁德凯,李正名,赵卫光,陈寒松. 2-取代氨基-5-吡唑基-1,3,4-噁二唑的合成及生物活性[J]. 应用化学, 2003, 20(7): 624-628 |
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| 作者姓名： | 袁德凯 李正名 赵卫光 陈寒松 |
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| 作者单位： | 南开大学 |
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| 基金项目： | “八六三”计划 ( #2 0 0 1AA2 3 5 0 11)，天津大学 /南开大学联合研究项目资助课题 |
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| 摘 要： | 取代氨基吡唑基噁二唑;2-取代氨基-5-吡唑基-1;3;4-噁二唑的合成及生物活性
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| 关 键 词： | 取代氨基吡唑基噁二唑 2-取代氨基-5-吡唑基-1 4-噁二唑的合成及生物活性 |
| 文章编号： | 1000-0518(2003)07-0624-05 |
| 收稿时间： | 2009-06-29 |
| 修稿时间： | 2002-12-04 |
Synthesis and Bioactivity of 2-Substituted amino-5-pyrazolyl-1,3,4-oxadiazoles |
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| YUAN De-Kai,LI Zheng-Ming,ZHAO Wei-Guang,CHEN Han-Song. Synthesis and Bioactivity of 2-Substituted amino-5-pyrazolyl-1,3,4-oxadiazoles[J]. Chinese Journal of Applied Chemistry, 2003, 20(7): 624-628 |
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| Authors: | YUAN De-Kai LI Zheng-Ming ZHAO Wei-Guang CHEN Han-Song |
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| Affiliation: | YUAN De-Kai,LI Zheng-Ming*,ZHAO Wei-Guang,CHEN Han-Song |
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| Abstract: | Methylthio-5-pyrazolyl-1,3,4-oxadizole 1 was oxidized by KMnO 4/HAc to give 2-methylsulfonyl-5-pyrazolyl-1,3,4-oxadiazole 2. Nucleophilic reaction of 2 with arylamines afforded the title compounds 2-arylamino-5-pyrazolyl-1,3,4-oxadiazoles 3. Structures of 2 and 3 were determined by elemental analysis, 1H NMR and mass spectrometry. The MS fragmentation patterns of compounds 2A and 2B were discussed. Bioassay showed that at a mass fraction of 0.005%, 2A and 2B inhibited Phoma asparagi by 40% and 60%. Compound 3A-5 and 3B-1 also have certain fungicidal activity. |
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| Keywords: | methylsulfonyl-pyrazolyl-oxadiazole synthesis bioactivity |
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