A new access to 3-substituted-1(2H)-isoquinolone by tandem palladium-catalyzed intramolecular aminocarbonylation annulation |
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Authors: | Dieudonné-Vatran Antoine Azoulay Michel Florent Jean-Claude |
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Affiliation: | Institut Curie, Centre de Recherche, 26 rue d'Ulm, Paris 75248, France. |
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Abstract: | An original tribromide derivative based, palladium-catalyzed synthesis of 3-substituted-1(2H)-isoquinolone is described based on a regioselective Suzuki-Miyaura C-C coupling on o-halo-(2,2-dihalovinyl)-benzene followed by a palladium catalyzed amination-carbonylation-cyclization reaction. This sequence efficiently proceeds to build up isoquinolone in fair to good yields over a one-pot 3-bond synthesis reaction. |
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