| Combination of hollow fiber-based liquid-phase microextraction with sweeping techniques in micellar electrokinetic chromatography for the determination of Strychnos alkaloids in human urine |
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| 作者姓名： | Xiao Huan Zang Cai Rui Li Qiu Hua Wu Chun Wang Dan Dan Han Zhi Wang |
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| 作者单位： | Xiao Huan Zang a，Cai Rui Li b，Qiu Hua Wu a，Chun Wang a，Dan Dan Han a，Zhi Wang a，*a Key Laboratory of Bioinorganic Chemistry，College of Science，Agricultural University of Hebei，Baoding 071001，Chinab College of Vocational and Technological Sanitation，Hebei University，Baoding 071002，China |
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| 基金项目： | 河北省自然科学基金;教育部留学回国人员科研启动基金 |
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| 摘 要： | A new method for the enrichment of Strychnos alkaloids in biological samples via liquid-phase microextraction (LPME) based on porous polypropylene hollow fibers in combination with on-line sweeping in micellar electrokinetic chromatography was developed. The calibration curve was linear over the range of 20-200 ng mL-1 for both strychnine and brucine in human urine sample. The detection limits (S/N=3:1) for strychnine and brucine were 1 ng mL-1 and 2 ng mL-1, respectively. The LPME-sweeping method has been successfully applied to the analysis of strychnine and brucine in real urine samples.
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| 关 键 词： | 人尿液 马钱子碱 分析检验 中空纤维 液相微提取法 扫描技术 胶束动电色谱法 |
| 收稿时间： | 2006-10-20 |
Combination of hollow fiber-based liquid-phase microextraction with sweeping techniques in micellar electrokinetic chromatography for the determination of Strychnos alkaloids in human urine |
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| Xiao Huan Zang Cai Rui Li Qiu Hua Wu Chun Wang Dan Dan Han Zhi Wang.Combination of hollow fiber-based liquid-phase microextraction with sweeping techniques in micellar electrokinetic chromatography for the determination of Strychnos alkaloids in human urine[J].Chinese Chemical Letters,2007,18(3):316-318. |
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| Authors: | Xiao Huan Zang Cai Rui Li Qiu Hua Wu Chun Wang Dan Dan Han Zhi Wang |
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| Institution: | 1. Key Laboratory of Bioinorganic Chemistry, College of Science, Agricultural University of Hebei, Baoding 071001, China;2. College of Vocational and Technological Sanitation, Hebei University, Baoding 071002, China |
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| Abstract: | A new method for the enrichment of Strychnos alkaloids in biological samples via liquid-phase rnicroextraction (LPME) based on porous polypropylene hollow fibers in combination with on-line sweeping in micellar electrokinetic chromatography was developed. The calibration curve was linear over the range of 20-200 ng mL-1 for both strychnine and brucine in human urine sample. The detection limits (S/N = 31) for strychnine and brucine were 1 ng mL-1 and 2 ng mL-1, respectively. The LPME-sweeping method has been successfully applied to the analysis of strychnine and brucine in real urine samples. |
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| Keywords: | Hollow fiber-based liquid-phase microextraction Sweeping MEKC Strychnos alkaloids Urine |
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