Use of alumina with anchored polymer coating as packing material for reversed-phase high-performance liquid chromatography

A new material with anchored polymer coating on alumina can be used as a packing material for the reversed-stationary phase of HPLC columns. The coatings are formed by in situ polymerization of maleic acid adsorbed on alumina with 1-octadecene, with cross-linking by 1,4-divinylbenzene. The chromatographic performance of this material was studied and compared with that of 20–30 μm octadecyl-bonded silica particles and a commercial column packed with 5 μm octadecyl-bonded silica. The results indicate that this new material is a promising alternative to silica-based reversed-phase packings due to its competitive performance and stability in acidic and basic media.