Addition de l'Hexafluoroacétone sur les Acides Carboxyliques—Mise en Évidence par RMN 1H et 19F. Application à l'Analyse d'un Mélange d'Acides |
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Authors: | N. Pellissier |
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Abstract: | The compound HO? C(CF3)2? O2CR results from nucleophilic addition of a carboxylic acid to the carbonyl group of hexafluoroacetone. I.r. and n.m.r. (1H, 19F) spectroscopy have been used to show that the addition is reversible. The addition is favoured by a lowering of the temperature and by the use of acids in which the group R is electron donating. Moreover, the chemical shift of the CF3 groups (or of the OH group) in the addition product is dependent on the nature of R. Thus, this reversible addition can be used as a method for the analysis of a mixture of carboxylic acids by n.m.r. spectroscopy. |
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